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The Gut-Brain Axis

A gut feeling: Why your stomach hurts when you're nervous Imagine the scenario: you are about to present an important talk on a stage with big, bright lights and lots of people...

What is Keto?

What is Ketosis? Ketosis is the metabolic state defined by elevation of ketone bodies. It’s generally accepted that one is in ketosis when blood levels of the primary ketone...

Dr. Dominic D’Agostino’s favorite books

Here is a short list of great books I have read over the last year. No matter how busy we get it is important to keep learning and growing, and that why I have posted about...
Ketones and the Mitochondria

Ketones and the Mitochondria

Ketogenic diets and ketone supplements have become an emerging area of research for the prevention, treatment, and management of several diseasese and disorders. Ketones are produced by the liver under conditions of low glucose and insulin, such as ketogenic diets and fasting, or can be taken as a...

The Gut-Brain Axis

The Gut-Brain Axis

A gut feeling: Why your stomach hurts when you're nervous Imagine the scenario: you are about to present an important talk on a stage with big, bright lights and lots of people in the audience. Suddenly, moments before you step on stage, you get nervous. We’ve all been there- despite months of...

What is Keto?

What is Keto?

What is Ketosis? Ketosis is the metabolic state defined by elevation of ketone bodies. It’s generally accepted that one is in ketosis when blood levels of the primary ketone body, beta-hydroxybutyrate (BHB), reach above 0.5 mmol/L. With the exception of ketosis induced via exogenous ketone...

Dr. Dominic D’Agostino’s favorite books

Dr. Dominic D’Agostino’s favorite books

Here is a short list of great books I have read over the last year. No matter how busy we get it is important to keep learning and growing, and that why I have posted about previous books in the past.  I tend to select books related to current and emerging work projects, but also spend several...

The Importance of Metabolic Health for Women’s Health

The Importance of Metabolic Health for Women’s Health

We previously wrote about the ketogenic diet for women, which we recommend you check out if you’re wondering how the ketogenic diet may differ for men and women. Research has and continues to show how much benefit anyone can gain from a ketogenic diet to restore and support their metabolic health,...

Understanding Non-Alcoholic Fatty Liver Disease

Understanding Non-Alcoholic Fatty Liver Disease

  This blog takes a step back and further defines NAFLD and the associated work we are doing in our current clinical trial (NCT04920058) on non-diabetics.  This ongoing research reminded us how ubiquitous this condition is and how it can advance without any overt signs detected in standard...

Bipolar Disorder Treatment: Choosing the Right Treatment

Bipolar Disorder Treatment: Choosing the Right Treatment

Have you ever come across a person diagnosed with bipolar disorder? They experience moments of manic or hypomanic episodes and depression. There are three types of bipolar disorders[1], namely Bipolar 1 disorder, Bipolar 2 disorder, and Cyclothymic disorder. Bipolar 1 disorder: a person with...

Metabolic Flexibility

Metabolic Flexibility

By now, you are likely in the know of how important insulin sensitivity is to our overall metabolic health and longevity. Insulin resistance essentially precedes type-2 diabetes, and is tightly linked with obesity and metabolic inflexibility. Metabolic inflexibility is thought to contribute to the...

Ketogenic Diet in Substance Abuse

Ketogenic Diet in Substance Abuse

Though ketogenic diet treatment may have a role in a number of substance use disorders (SUDs), so far most studies have addressed the role of keto diets with respect to alcohol abuse. Alcohol Use Disorder (AUD), also known as alcoholism or alcohol dependence, is characterized by strong cravings,...

How do ketones work?

How do ketones work?

We know from previous studies that our brain metabolism can readily use ketone bodies as a primary source of fuel for the brain.  What is more, it is widely accepted that ketone bodies (e.g., βHB), are not only a potential energy source for different tissues of the body, but also potent signaling...

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