Educating others on Metabolic Therapies and the Ketogenic Diet

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“We provide accurate information to the public on nutrition and metabolic therapies. This website is a resource and educational platform for people interested in these topics. We are committed to move ketogenic science into human applications.” -Dr. Dominic D`Agostino

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What is Keto?

At its simplest, a ketogenic diet is a very low carbohydrate, high fat, moderate protein diet. The purpose of following a ketogenic diet is to put the body into a state of ketosis where the body relies on burning fat for fuel instead of sugar.

See, the body has two major fuels – sugar or fat. Today, most people exist primarily in the sugar-burning state due to constant access to food high in sugar and processed carbohydrates.  Generally speaking, high carb diets may not be optimal if bodyweight, appetite and blood glucose remain above healthy limits.  Carbohydrate restriction is one option to improve these variables and metabolic health in general.

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High Fat

Moderate Protein

Low Carb

Paired With Exercise

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"Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy (HBO2T) saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia."

Poff AM, Ari C, Seyfried TN, D’Agostino DP (2013) The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic MetastaticCancer. PLoS ONE 8(6): e65522. doi:10.1371/journal.pone.0065522

"Certain conditions, such as inflammation, oxidative stress or seizure disorders can be exacerbated by elevated blood glucose. Therefore, managing glycemia may be vital to mitigating patient risk and improving prognosis" "Results indicate that exogenous ketones were efficacious in reducing blood glucose levels within and outside the context of exercise..."

Ari, Csilla; Murdun, Cem; Koutnik, Andrew P.; Goldhagen, Craig R.; Rogers, Christopher; Park, Collin; Bharwani, Sahil; Diamond, David M.; Kindy, Mark S.; D’Agostino, Dominic P.; Kovács, Zsolt. 2019. “Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models” Nutrients 11, no. 10: 2330. https://www.mdpi.com/2072-6643/11/10/2330

"The present study suggests that the exogenous ketone supplement (EKS)-evoked effects on blood R-βHB and glucose levels may be modulated by both age and sex. Thus, the age- and gender-dependent modulatory effects of EKSs on blood R-βHB and glucose concentrations should be taken into consideration during the administration of metabolic-based therapies for the treatment of different diseases. "

Kovács Z, Brunner B, D’Agostino DP and Ari C (2021) Age- and Sex-Dependent Modulation of Exogenous Ketone Supplement-Evoked Effects on Blood Glucose and Ketone Body Levels in Wistar Albino Glaxo Rijswijk Rats. Front. Neurosci. 14:618422. 
doi:10.3389/fnins.2020.618422

"There is increasing experimental evidence that ketone‐induced anti‐seizure properties function through a multiplicity of mechanisms associated with suppression of neuronal hyperexcitability, inflammation, and redox stress. These mechanisms include but are not limited to: activation of inhibitory adenosine and ATP‐sensitive potassium channels; enhancement of mitochondrial function and reduction in oxidative stress; attenuation of neuronal excitability by modulating vesicular glutamate transporters or VGLUTs, and enhancement of central γ‐aminobutyric acid (GABA) synthesis."

Ari, C., Koutnik, A. P., DeBlasi, J., Landon, C., Rogers, C. Q., Vallas, J., Bharwani, S., Puchowicz, M., Bederman, I., Diamond, D., Kindy, M. S., Dean, J. B., D′Agostino, D. P. Delaying latency to hyperbaric oxygen‐induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements. Physiol Rep, 7 ( 1), 2019, e13961, https://doi.org/10.14814/phy2.13961

"Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy (HBO2T) saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia."

Poff AM, Ari C, Seyfried TN, D’Agostino DP (2013) The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic MetastaticCancer. PLoS ONE 8(6): e65522. doi:10.1371/journal.pone.0065522

"Certain conditions, such as inflammation, oxidative stress or seizure disorders can be exacerbated by elevated blood glucose. Therefore, managing glycemia may be vital to mitigating patient risk and improving prognosis" "Results indicate that exogenous ketones were efficacious in reducing blood glucose levels within and outside the context of exercise..."

Ari, Csilla; Murdun, Cem; Koutnik, Andrew P.; Goldhagen, Craig R.; Rogers, Christopher; Park, Collin; Bharwani, Sahil; Diamond, David M.; Kindy, Mark S.; D’Agostino, Dominic P.; Kovács, Zsolt. 2019. “Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models” Nutrients 11, no. 10: 2330. https://www.mdpi.com/2072-6643/11/10/2330

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